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In the ATTAIN 1 phase 3, randomized trial, the use of orforglipron, an oral glucagon like peptide 1 receptor agonist, led to significant mean body weight reductions in patients with obesity, as compared with placebo. Full GLP 1 Agonists Examples: Which One Wins? GLP 1 and health: Beyond weight loss in the Ozempic era Understanding GLP 1 Drugs: Cost, Safety, and Access in Context NAM Prolonged Activation of the GLP 1 Receptor via Covalent Capture ACS Chemical Biology GLP 1 receptor agonists How Wegovy, Ozempic, and Mounjaro work
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This is a great, my Yorker is inside all day and this gives him a place to relieve him self , he uses it and also goes outside. It’s easy to clean no mess.
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Reviewed in the United States on October 21, 2025
★★★★★ 2
Too small for large dogs, better for medium sized dogs.
Made welll. Too small of a box for labs and retrievers. I purchased large pans and washable mats .
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Reviewed in the United States on April 15, 2025
★★★★★ 5
Worth it! No more mess
My puppy loves to eat disposable pads and vomits after (I do not have time to wash reuseable ones; also, the smell it leaves in the washer is a nono). I go through around at least 4 pads a day (bleeding money) and constantly hadb to tuck them under the playpen hoping he doesn't get a piece of it. But when he started to dig through the pad even when it was on a regular pad holder, i lost it.
This right here, he cant do anything!
I get to only use 1 disposable pad a day: every morning, i take out the top mesh part, spray it down with odor eliminator/disinfectant, wait few minutes, and then spray down everything with a garden hose. Tap a bit, wipe it down with just 1 paper towel and put it back over a fresh pad. When he poops, i just pick it up like how i pick poop outside and then disinfect the area. My boy Lucas doesnt stink anymore (he tend to sit on the other pad holder where pee is still wet), and i dont have to go outside of the heat. $55 is well worth it in the long run.
⚠️CAUTION⚠️
*Make sure your pet has short nails. Long nails that curves down will get stuck in the holes. If they get startled and twist themselves, BIG PROBLEM. Please dont indirectly hurt your doggie.
Edit: newest set up in the pic. He pees and poops exclusively there now since introduced.
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Reviewed in the United States on August 22, 2024
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Brilliant fun for dog, except for...
I have a 3yo German Shepherd Dog (GSD) and he can be very hard on toys. On days 1 and 2 he had such fun and we laughed at his good times!
Then...Day 3...cue the Jaws Music... While I was away for 10 minutes, he dismantled the ball into tiny pieces! Even so, the ball continued to light up, make sounds and entertain my GSD!!
Coolest dog toy ever!
If you have a heavy chewer....watch out!
Otherwise, I highly recommend!!
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